Our new Very clear+ tissue clearing technique is the sole process that delipidates samples without any improve in morphology and with minimum influence on structural integrity.

Megatome is actually a vibrating microtome meant to part a wide choice of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With substantial blade vibrating frequency and minimized blade deflection, Megatome permits high-throughput tissue sectioning with uniform surface area profile, and also negligible tissue harm and information loss.

Antibodies may possibly acquire months to diffuse as a result of only some millimeters of tissue, with a steep labeling gradient from surface to Main.

Megatome is suitable for precision: the blade vibrates at a greater frequency and larger amplitude selection than other microtomes, and contains a exclusive deflection Management mechanism.

SE employs a rotational electric field to disperse remarkably electromobile molecules (such as antibodies or surfactant micelles) all over a porous sample devoid of harmful electrically billed constructions throughout the tissue. This permits 2-four working day clearing of intact organs,

Our preformulated EasyIndex solution raises and homogenize the refractive index of delipidated tissue samples, megatomi.com rendering them entirely transparent. This allows light penetration into the sample and assures the acquisition of superior-resolution, in-target graphic information.

Megatome is actually a novel microtome that permits for top-precision sectioning of a variety of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with negligible tissue damage and knowledge reduction.

It’s time for you to improve your microtome to Megatome. With accurate high-frequency slicing for an unmatched range of sample dimensions and kinds – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for varied apps.

The SmartSPIM gentle sheet microscope gives unparalleled resolution and acquisition speed all over intact tissue volumes, while its modular structure helps you to up grade and customize individual parts.

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Defend avoids the variability of hydrogel embedding and the data loss from PFA preservation, defending specimens for numerous rounds of processing.

Leverage the Apparent+ tissue clearing method, together with eFLASH and patented stochastic electrotransport technologies, to quickly very clear and label entire organs. Crucial highlights and functions contain:

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